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. 2021 Nov 12;11:735180. doi: 10.3389/fonc.2021.735180

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Copyright © 2021 Pu, Zhang, Yan, Li, Liu, Jian, Mahgoub, Gu, Xiong and Zou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MICAL2 promotes the proliferation of glioma cells in vivo. (A) Schematic of the MICAL2 knockdown and NC in patient-derived GBM orthotopic xenograft model (created with biorender.com) (n = 15 for each group). (B) HE staining of orthotopic brain tumor. (C) Bioluminescence image of orthotopic brain tumor. (D, E) MRI image of orthotopic brain tumor, and the tumor size were analyzed. (F, G) PCNA, cyclin D, vimentin, N-cadherin, E-cadherin, and GAPDH expression detected by Western blotting. Data are shown as the means ± SEM of three experiments. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001.