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. 2021 Nov 12;11:743824. doi: 10.3389/fonc.2021.743824

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Copyright © 2021 Wu, Yu, Xiong, Zhang, Lin, Zhang, Wu, Wang, Liu and Xie

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation between α3 and mTOR activity in 91 CRC tissues. (A) Representative images of IHC staining for α3 in CRC tissues and matched adjacent normal tissues. (B, C) The relationships between α3 and TNM stage (B) and metastasis (C) were determined. (D, E) The correlation between α3 and p-4EBP1 was evaluated in 91 CRC tissues and matched adjacent normal tissues. (F) A model of CRC cell metastasis driven by elevated α3 expression via the p53-PTEN/IGFBP3-mTOR axis, which is blocked by bufalin. Scale bar, 50 μm.