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. 2021 Nov 30;11:23081. doi: 10.1038/s41598-021-02508-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of MMP modulation on coronary artery atherosclerosis in apolipoprotein E-deficient (Apoe^-/-) mice. Quantification and representative images of coronary atherosclerotic burden as assessed in EVG-stained hearts from 36-week high-fat fed Apoe^-/- mice deficient for (A) MMP-7, (B) MMP-9, and (C) MMP-12, in comparison to their respective Apoe single knockout controls. Atherosclerotic burden (%) is presented as average plaque burden/coronary artery/mouse. Statistical significance is reported as ***P < 0.001 using unpaired Students t-test. Scale bar represents 1 mm and is applicable to all panels. In all cases, n = 10/group.