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. 2021 Dec 1;8:253. doi: 10.1038/s41438-021-00679-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a In vivo evidence of inhibitor treatment. b Analysis of target metabolites under stress. c Analysis of transcription level of epigenetic factors under stress. YES or NO denotes judging whether DNA methylation and histone acetylation are involved in the regulation of secondary metabolism in tea plants. HOW represents the mechanism of DNA methylation and histone acetylation involvement in the regulation of secondary metabolism in tea plants. TFs transcription factors, HDACs histone deacetylases, MBDs methyl-binding domain protein, ChIP chromatin immunoprecipitation, EMSA electrophoretic mobility shift assay, Y2H yeast two-hybrid, BiFC bimolecular fluorescence complementation, Co-IP coimmunoprecipitation.