Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Nov 30;6:101. doi: 10.1038/s41525-021-00264-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — a, b Bubble graph showing the percentage of transcriptionally active integration loci per tumor in CESC (a) and HNSCC (b) samples relative to the number of integration loci per tumor; 100% indicates that all integration loci are active in that tumor. Orange, blue and gray circles represent tumors with a single, multiple or no transcriptionally active loci, respectively. Circle size indicates the number of samples per grouping (for CESC, largest, n = 86 and smallest, n = 1; for HNSCC, largest, n = 21 and smallest, n = 1). Three HNSCC samples (TCGA-CR-6482, TCGA-CN-5374, and TCGA-CR-7404) were reported as integration negative from RNA-seq³² but had a single or multiple integration loci detected through WGS⁵ and were therefore classified as transcriptionally inactive. c Bar chart showing the number of CESC integration loci that are transcriptionally active or inactive for viral oncogene expression at integration hotspots. Association between viral oncogene transcription and integration hotspots was based on a Fisher’s exact test (two-tailed; **P < 0.01).