Fig. 8.

Cholesterol depletion enhances TRPV4-mediated membrane currents in Xenopus oocytes. A: Representative current traces from TRPV4-expressing oocytes and uninjected control oocytes in control solution or after 45 min exposure to 50 μM MβCD. B: I/V curves of TRPV4-expressing oocytes exposed to control solution or MβCD, with uninjected oocytes in inset. Summarized currents obtained at −85 mV are shown in the lower inset. The magnitude of TRPV4-mediated currents (at V_m = −85 mV) was compared using Student's t-test. ∗∗P < 0.01; N = 9. NS, not significant.