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. 2021 Nov 22;48:102197. doi: 10.1016/j.redox.2021.102197

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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figs5 — IEndogenous adropin is beneficial in the preservation of BBB integrity in male mice subjected to ischemic stroke. BBB permeability was assessed by measurement of immunoglobulin G (IgG) and albumin at 48h after pMCAO in the ipsilateral and contralateral cerebral cortices. Deficiency of the Enho gene (Enho^−/−) resulted in significant extravasation of IgG (A) and albumin (B) into the ipsilateral cortex compared to Enho^+/+ mice, while overexpressing adropin (AdrTg) reduced the leak of IgG and albumin into ischemic brain compared to the corresponding wild-type mice (C, D). Two-way ANOVA with Bonferroni post-tests, **P<0.01, ***P<0.001. Enho^+/+ (n=9), Enho^-/- (n=14), WT (n=5), AdrTg (n=14).