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. 2021 Nov 30;4:1342. doi: 10.1038/s42003-021-02845-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a, c A montage of 2D FSE T2w MRI brain slices of representative Mbnl1^+/+/Mbnl2^+/+ (wild-type control) and Mbnl1^+/−/Mbnl2^−/− mice that underwent in vivo scanning are shown, respectively. Mouse identifier numbers are shown in parenthesis. b, d Manually defined, color-filled regions of interest (ROI) overlaid onto structural FSE T2w MRI slices are shown. All ROIs that are significantly different between the two genotypes are displayed. Color code: white matter regions, which include the anterior commissure and the corpus callosum/external capsule (yellow). Gray matter regions, which include the isocortex (red), the caudoputamen (blue), the hippocampus (green), the inter-/midbrain (orange), and the hindbrain (pink). Calculated areas from the ROIs were multiplied by the image-slice thickness to generate ROI volumes shown in Figs. 2 and 3. The olfactory bulb was excluded in volume measurements. Slice positions are identified based on Bregma locations. The slice where the anterior commissure is connected between hemispheres approximates Bregma, which is defined as 0.0 mm. Going from rostral to caudal slice positions, boxes indicate structural landmarks that include Bregma (red box), the last slice containing hippocampal regions (green box), and the end of the brain (yellow box). Slice thickness = 0.5 mm. Scale bar = 1 mm.