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. 2021 Nov 30;4:1342. doi: 10.1038/s42003-021-02845-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a 3D rendering of representative whole-brain 2D FSE T2w MRIs for 2-mo Mbnl1^+/+/Mbnl2^+/+, Mbnl1^−/−, Mbnl2^−/−, and Mbnl1^−/−/Mbnl2^+/− mice are shown. Colored regions are isocortex and cerebellum (red), hindbrain (pink), white matter areas (yellow), and olfactory gray matter areas (gray). The olfactory bulb was excluded in volume measurements. Scale bar = 2.0 mm. b Whole-brain measurements (mean ± SD) are shown. c Representative axial brain slices from FSE T2w MRI scans where apparent ventricle volumes were defined from hyperintense regions along ventricle locations (yellow filled). Scale bar in 2D axial images denotes 1 mm. d, e Apparent ventricle volume and percent apparent ventricle volume/whole-brain volume (mean ± SD) are shown. Black brackets: Dunnett’s test; Purple brackets: two-tailed t-test. Error bars are standard deviations (SD). In all cases, *p < 0.05, **p < 0.01.