Table 1.

Summary of clinicopathologic findings for three cases (1–3) of unilateral, painless salivary gland enlargement

Case	Clinical features	Laboratory findings	CT findings	Histopathology	IgG/IgG4 immunohistochemistry
1	58-year-old female with painless, firm, left submandibular gland enlargement	ANA elevated (1:320), ESR slightly elevated (27) IgG4, CRP, SS-A, SS-B within normal limits	Slight enlargement of left submandibular gland	Chronic inflammation, numerous plasma cells, cellular storiform interlobular fibrosis	Positive for IgG + plasma cells; negative for IgG4 + plasma cells (0–1/hpf in highest area)
2	76-year-old male with painless, firm, right submandibular gland enlargement	Not studied	Slightly enlarged right submandibular gland with normal parenchyma	Moderate chronic inflammation rich in plasma cells, interlobular dense fibrosis, foreign giant cell reaction to calcific debris and polarizable crystals	Positive for IgG + and IgG4 + plasma cells with highest IgG4 count—48/hpf and IgG4:IgG ratio ~ 30%
3	69-year-old male with painless, firm, left sublingual gland enlargement	IgG4 within normal limits	Enhancing mass within the left sublingual space; no bony erosion or lymphadenopathy	Dense fibrosis with preservation of lobular architecture	Scant IgG + plasma cells; negative for IgG4 + plasma cells (0–1/hpf in highest area)