Fig. 4.

Molecular genetics study results: (a) EWSR1 break-apart FISH failed to detect the rearrangement of EWSR1-PATZ1. Due to the proximity of EWSR1 and PATZ1genes, the break-apart of the EWSR1 locus was not observed in the majority of tumor cells. (b) The EWSR1-PATZ1 fusion was visualized on IGV. The soft-clipped reads supporting the junction between the end of exon 9 of EWSR1 gene (NM_013986) and exon 1 of PATZ1 gene (NM_014323) was shown. The fusion product was predicted to be translated in-frame