Table 2.
Morphologic types and features by high risk HPV status (positive versus negative)
| HPV positive | HPV negative | Entire cohort (%) | p value | |
|---|---|---|---|---|
| All patients | 224 (86.5) | 35 (13.5) | 259 | |
| Histologic type | ||||
| Conventional | ||||
| Nonkeratinizing | 133 (59.4) | 4 (11.4) | 137 (52.9) | < 0.001* |
| Nonkeratinizing with maturation | 54 (22.3) | 6 (17.1) | 60 (23.2) | 0.26 |
| Keratinizing | 9 (4.0) | 23 (65.7) | 32 (12.4) | < 0.001* |
| Subtypes | ||||
| Adenosquamous (Including Ciliated) | 6 (2.7) | 0 | 6 (2.3) | 0.24** |
| Lymphoepithelial | 7 (3.1) | 1 (2.9) | 8 (3.1) | |
| Basaloid | 3 (1.3) | 0 | 3 (1.2) | |
| Papillary | 12 (5.4) | 1 (2.9) | 13 (5.0) | |
| Anaplasia present? | 53 (23.7) | 10 (28.6) | 63 (24.3) | 0.53 |
| Multinucleation present? | 87 (38.8) | 6 (17.1) | 93 (35.9) | 0.013 |
| Anaplasia and/or Multinucleation present? | 105 (46.9) | 13 (37.1) | 118 (45.6) | 0.28 |
| Multinucleation Index (MNI) (Average) | 5.0 | 2.7 | 4.7 | |
| MNI 1 or more | 123 (54.9) | 15 (42.9) | 112 (43.2) | 0.88 |
| MNI 3 or more | 93 (41.5) | 7 (20.0) | 100 (38.6) | 0.98 |
| MNI 11 or more | 34 (15.1) | 3 (8.6) | 37 (14.3) | 0.34 |
| Stromal desmoplasia (%) (Average) | 8.6% | 18.0% | 9.8% | |
| 1% or more | 137 (61.1) | 31 (88.6) | 168 (64.9) | < 0.001 |
| 11% or more | 54 (24.1) | 17 (48.6) | 71 (27.4) | 0.001 |
| 31% or more | 12 (5.4) | 5 (14.2) | 17 (6.6) | 0.035 |
| Maturing squamous differentiation (%) (Average) | 16.2% | 75.4% | 24.2% | |
| 1% or more | 165 (73.7) | 32 (91.4) | 197 (76.1) | 0.022 |
| 11% or more | 67 (29.9) | 30 (85.7) | 97 (37.5) | < 0.0001 |
| 31% or more | 36 (16.1) | 26 (74.3) | 62 (23.9) | < 0.0001 |
| 51% or more | 23 (10.3) | 26 (74.3) | 49 (18.9) | < 0.0001 |
*Value for nonkeratinizing vs nonkeratinizing with maturation vs keratinizing
**Value for all subtypes combined vs all conventional SCC types