Table 3.
Morphologic types and features by high risk HPV type
| HPV16 | Non HPV16 | p value | |
|---|---|---|---|
| All patients | 212 (94.6) | 12 (5.4) | |
| Histologic type | |||
| Conventional | |||
| Nonkeratinizing | 128 (60.4) | 6 (50.0) | 0.25* |
| Nonkeratinizing with maturation | 51 (24.1) | 3 (25.0) | 0.77* |
| Keratinizing | 7 (3.3) | 2 (16.7) | 0.036* |
| Subtypes | |||
| Adenosquamous (Including Ciliated) | 6 (2.8) | 0 | 0.90** |
| Lymphoepithelial | 7 (3.3) | 0 | |
| Basaloid | 3 (1.4) | 0 | |
| Papillary | 11 (5.2) | 1 (8.3) | |
| Anaplasia present? | 50 (23.6) | 3 (25.0) | 0.77 |
| Multinucleation present? | 83 (39.2) | 4 (33.3) | 0.73 |
| Anaplasia and/or Multinucleation present? | 99 (46.7) | 6 (50.0) | 0.45 |
| Multinucleation Index (MNI) (Average) | |||
| MNI 1 or more | 117 (55.2) | 6 (50.0) | 0.51 |
| MNI 3 or more | 88 (41.5) | 5 (41.7) | 0.39 |
| MNI 11 or more | 31 (14.6) | 3 (25.0) | 0.39 |
| Stromal desmoplasia (%) (Average) | |||
| 1% or more | 129 (60.8) | 7 (58.3) | 0.61 |
| 11% or more | 51 (24.1) | 2 (16.7) | 0.20 |
| 31% or more | 10 (4.7) | 2 (16.7) | 0.11 |
| Maturing squamous differentiation (%) (Average) | |||
| 1% or more | 157 (74.1) | 8 (66.7) | 0.22 |
| 11% or more | 62 (29.2) | 5 (41.7) | 0.30 |
| 31% or more | 33 (15.6) | 3 (25.0) | 0.43 |
| 51% or more | 20 (9.4) | 3 (25.0) | 0.10 |
*Value for nonkeratinizing vs nonkeratinizing with maturation vs keratinizing
**Value for all variants combined vs all conventional SCC types