Table 4.

Morphologic types and features by high risk HPV 16 lineage

	A	B	C	D	p value*
All patients	191	1	4	16
Histologic type
Conventional
Nonkeratinizing	116 (60.7)	0	1 (25.0)	11 (64.7)	0.57
Nonkeratinizing with maturation	44 (23.0)	1	2 (50.0)	3 (18.8)	0.33
Keratinizing	7 (3.7)	0	0	0	0.36
Subtypes
Adenosquamous (Including Ciliated)	6 (3.1)	0		0	0.89
Lymphoepithelial	6 (3.1)	0	1 (25.0)	0
Basaloid	2 (1.0)	0	0	1 (5.9)
Papillary	10 (5.2)	0	0	1 (5.9)
Anaplasia present?	48 (25.1)	0	1 (25.0)	1 (5.9)	0.09
Multinucleation present?	76 (39.8)	0	2 (50.0)	5 (29.4)	0.47
Anaplasia and/or Multinucleation present?	89 (46.6)	0	3 (75.0)	7 (41.2)	0.92
Multinucleation index (MNI) (Average)
MNI 1 or more	104 (54.5)	0	4 (100.0)	9 (52.9)	0.76
MNI 3 or more	81 (42.4)	0	2 (50.0)	5 (29.4)	0.30
MNI 11 or more	28 (14.7)	0	2 (50.0)	1 (5.9)	0.87
Stromal desmoplasia (%) (Average)
1% or more	115 (60.2)	1	3 75.0)	10 (58.8)	0.76
11% or more	46 (24.1)	1	1 (25.0)	3 (17.6)	0.89
31% or more	9 (4.7)	0	1 (25.0)	0	0.97
Maturing squamous differentiation (%) (Average)
1% or more	141 (73.8)	1	3 (75.0)	12 (70.6)	0.91
11% or more	54 (28.3)	1	2 (50.0)	5 (29.4)	0.43
31% or more	28 (14.7)	1	0	3 (17.6)	0.32
51% or more	17 (8.9)	1	0	2 (11.8)	0.47

^*Value for HPV 16 subtype A vs other subtypes