Table 5.

Morphologic types and features by high risk HPV type 16 sublineage

	A1	A2	A3	A4	C	D3	Any A	p value*
All patients	112	62	3	14	4	13	191
Histologic Type
Conventional
Nonkeratinizing	62 (55.4)	41 (66.1)	2 (66.7)	10 (71.4)	1 (25.0)	9 (69.2)	115 (60.2)	0.57
Nonkeratinizing with maturation	29 (25.9)	11 (17.5)	1 (33.3)	4 (28.6)	2 (50.0)	3 (23.1)	43 (22.5)	0.38
Keratinizing	6 (5.4)	1 (1.6)	0	0	0	0	7 (3.7)	1.0
Subtypes
Adenosquamous (Including Ciliated)	6 (5.4)	0	0	0	0	0	6 (3.1)	1.0**
Lymphoepithelial	3 (2.7)	3 (4.8)	0	0	1 (25.0)	0	6 (3.1)
Basaloid	0	2 (3.2)	0	0	0	1 (7.7)	2 (1.0)
Papillary	6 (5.4)	4 (6.3)	0	0	0	0	10 (5.2)
Anaplasia present?	25 (22.3)	19 (30.2)	2 (66.7)	2 (14.3)	1 (25.0)	1 (7.7)	48 (25.1)	0.25
Multinucleation present?	41 (36.6)	27 (42.9)	2 (66.7)	6 (4.3)	2 (50.0)	5 (38.5)	76 (39.8)	1
Anaplasia and/or Multinucleation present?	49 (43.8)	32 (50.8)	2 (66.7)	6 (4.3)	3 (75.0)	7 (53.8)	89 (46.6)	0.47
Multinucleation Index (MNI) (Average)	4.5%	5.2%	13.7%	7%	9.8%	2.6%	5%
MNI 1 or more	58 (51.8)	36 (57.1)	2 (66.7)	8 (57.1)	4	9 (69.2)	104 (54.5)	0.21
MNI 3 or more	43 (38.4)	29 (46.0)	2 (66.7)	7 (0.5)	2 (50.0)	5 (38.5)	81 (42.4)	1
MNI 11 or more	12 (10.7)	10 (15.9)	2 (66.7)	4 (28.6)	2 (50.0)	1 (7.7)	28 (14.7)	0.73
Stromal desmoplasia (%) (Average)	8.5%	8.7%	8.3%	5.8%	12.5%	6.8%	8.4%
1% or more	60 (53.6)	44 (69.8)	2 (66.7)	10 (71.4)	3 (75.0)	9 (69.2)	116 (60.7)	0.8
11% or more	26 (23.2)	18 (28.6)	1 (33.3)	2 (14.3)	1 (25.0)	3 (23.1)	47 (24.6)	1
31% or more	8 (7.1)	1 (1.6)	0	0	1 (25.0)	0	9 (4.7)	0.6
Maturing squamous differentiation (%) (Average)	18.6%	9.3%	2%	14.6%	10%	19.5%	15%
1% or more	83 (74.1)	46 (73.0)	2 (66.7)	10 (71.4)	3 (75.0)	10 (76.9)	141 (73.8)	1
11% or more	39 (34.8)	12 (19.0)	0	3 (21.4)	2 (50.0)	5 (38.5)	54 (28.3)	0.42
31% or more	22 (19.6)	3 (4.8)	0	3 (21.4)	0	4 (30.8)	28 (14.7)	0.49
51% or more	13 (11.6)	2 (3.2)	0	2 (14.3)	0	2 (15.4)	17 (8.9)	0.67

*Value for HPV 16 A sublineage As vs other sublineages

**Value for all variants combined vs all conventional SCC types