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. 2021 Nov 30;11:23163. doi: 10.1038/s41598-021-02667-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Traditional enhancement image and pharmacokinetic images of IMCC and HCC. For the patients with IMCC, the HAP image showed high perfusion in the margin and relatively low perfusion in the center. PVP images showed hyperperfusion from the peripheral to the central part of the tumor. For patients with HCC, the HAP image showed high perfusion in the rim, while the PVP image showed homogeneous low perfusion in the complete lesion. The AEF images both showed heterogeneous high perfusion for two tumor lesions. HAP Hepatic arterial supply perfusion, PVP Portal venous supply perfusion, AEF Arterial enhancement fraction, IMCC Intrahepatic mass-forming cholangiocarcinoma, HCC Hepatocellular Carcinoma.