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. 2021 Nov 30;11:23176. doi: 10.1038/s41598-021-02638-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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β-diversity in oral squamous cell carcinoma patients with metastasis and no metastasis. Principal coordinated analysis of unweighted (A) and weighted (B) unifrac distance of oral microbiota. Each point represents individual sample. Average unweighted (C) and weighted (D) unifrac distance representing intragroup and intergroup within oral microbiota. Permutational multivariate analysis of variance was performed with the unweighted unifrac distance index (Permanova p = 0.031) and weighted unifrac distance index (Permanova p = 0.069). Metastasis yes/yes in X axis means the sequence distance between one sample in the yes group and another sample in the yes group.