Skip to main content
. 2021 Mar 3;42(12):2106–2119. doi: 10.1038/s41401-021-00617-4

Fig. 9. Schematic diagram showing the proposed mechanism of AKI in CKD progression.

Fig. 9

During AKI to CKD progression, loss of tubular FIH-1 contributed to the activation of the HIF-1α C-TAD, promoting the progression of CKD by transcriptionally upregulating KLF5, a HIF-1α C-TAD-specific target gene.