Table 3.
The median overall survival and Cox regression analysis of metastatic gastric cancer by treatment modalities in Taiwan from 2008 to 2015.
| Median overall survival (OS) | Death rate | Univariate hazard ratio | Multivariable hazard ratio | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Months | 95% CI | P-value | HR | 95% CI | P-value | HR | 95% CI | P-valuea | ||
| Treatment modalities | ||||||||||
| Chemotherapy alone | 7.0 | 6.7–7.3 | < 0.001 | 96.6 | 1.00 | 1.00 | ||||
| Surgery alone | 3.9 | 3.3–4.5 | 96.4 | 1.22 | 1.10–1.36 | < 0.001 | 1.17 | 1.04–1.31 | 0.007 | |
| Chemotherapy + surgery | 14.2 | 13.4–15.0 | 85.8 | 0.47 | 0.44–0.51 | < 0.001 | 0.47 | 0.43–0.51 | < 0.001 | |
| Supportive care | 1.9 | 1.8–2.0 | 99.3 | 3.23 | 3.01–3.46 | < 0.001 | 2.98 | 2.77–3.21 | < 0.001 | |
| Treatment modalities with surgery by surgical margin | ||||||||||
| Surgery alone | ||||||||||
| R0 resection (N = 256) | 4.7 | 3.7–5.8 | 0.685 | 94.9 | 1.01 | 0.89–1.16 | 0.842 | 0.97 | 0.84–1.11 | 0.607 |
| R1 + R2 resection (N = 133) | 3.2 | 2.8–3.7 | < 0.001 | 99.2 | 1.96 | 1.65–2.34 | < 0.001 | 1.87 | 1.57–2.23 | < 0.001 |
| Chemotherapy + surgery | ||||||||||
| R0 resection (N = 722) | 15.1 | 13.9–16.3 | < 0.001 | 84.5 | 0.44 | 0.4–0.48 | < 0.001 | 0.43 | 0.40–0.48 | < 0.001 |
| R1 + R2 resection (N = 295) | 11.7 | 10.2–13.1 | < 0.001 | 89.2 | 0.57 | 0.5–0.65 | < 0.001 | 0.56 | 0.49–0.63 | < 0.001 |
aAdjusted by sex, age at diagnosis, year of diagnosis, tumor grade, and hospital level.