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. 2021 Nov 12;11:796839. doi: 10.3389/fonc.2021.796839

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Copyright © 2021 Liu, Yang, Huang, Lv, Yang, Zhao, Zhao and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The proposal model of the present work. FBI-1 can downregulate the expression level of miR-3692-5p, thereby causing the upregulation of HIF-1a expression and finally downregulating the sensitivity of HCC cells to molecular targeted drugs by inducing the Warburg effect of HCC cells. The siRNA of FBI-1 is used to inhibit the expression of FBI-1. At this time, the expression level of miR-3692-5p is upregulated, and then by inhibiting the expression of HIF-1α and inhibiting the Warburg effect of HCC cells, it reverses the resistance of HCC cells to molecular targeted drugs.