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siFBI-1 enhances the sensitivity of MHCC97-H cells to molecular targeted agents.
| Agents | Control | siFBI-1 | siFBI-1 + HIF-1αMut |
|---|---|---|---|
| IC50 values (μmol/L) | |||
| Sorafenib | 1.06 ± 0.22 | 0.22 ± 0.94 | 1.54 ± 0.57 |
| Regorafenib | 0.97 ± 0.10 | 0.25 ± 0.08 | 1.03 ± 0.24 |
| Lenvatinib | 0.75 ± 0.32 | 0.17 ± 0.03 | 1.01 ± 0.88 |
| Cabozantinib | 0.46 ± 0.12 | 0.10 ± 0.01 | 0.78 ± 0.14 |
