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. 2021 Nov 12;12:763065. doi: 10.3389/fimmu.2021.763065

Figure 9.

Figure 9

Behavioral assessment of the ICV cohort. (A, B) The anti-CXCL13 treated group had more mice show a preference (blue) over no preference (red) for the novel placement or object than the IgG control groups in both memory assessment tasks. OP task: Non-surgery: n=10, Anti-CXCL13 treated: n=12, IgG control: n=12; ***p=0.0009. OR task: Non-surgery: n=10, Anti-CXCL13 treated: n=11, IgG control: n=12; p=0.062. One mouse was excluded from the treated group in the OR task results due to an inadequate exploration time during the training trial. (C) Both antibody groups had significantly lower depression-like behavior than the non-surgery group. Anti-CXCL13 Treated: 34.33 ± 4.23% and IgG Control: 45.94 ± 4.79%, p=0.14. PBS control: n=10, Anti-CXCL13 treated: n=10, IgG control: n=11. One mouse in each of the treated and IgG groups was excluded after inability to float during the test. OP, object placement; OR, object recognition. ***p ≤ 0.001.