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. 2021 Nov 13;3(4):fcab259. doi: 10.1093/braincomms/fcab259

Figure 1.

Figure 1

Workflow of the PC-FDC analysis. (A) Within-lesion (black mask overlaid in the MNI template) functional connectivity was computed indirectly in an independent sample of controls. (B) The voxel-averaged matrix was fed into a principal component analysis. (C) The first component was considered and projected back to lesion space. The time-series of the voxels overlapping with the 20% of the higher PC1-coefficient distribution was averaged and used to compute mean functional connectivity maps. (D) Lesion frequency maps. PC-FDC methodology identified lesion-voxels mainly in the GM. (E) Functional maps computed with the FDC and PC-FDC approaches were compared.