. 2021 Oct 19;6(4):714–719. doi: 10.1002/epi4.12540

TABLE 2.

Predictive value of a 2‐week posttreatment outpatient prolonged EEGs to detect ongoing infantile spasms

		Ongoing IS		Sensitivity	Specificity	PPV	NPV	NLR
		Yes	No	Sensitivity	Specificity	PPV	NPV	NLR
		% (n)		(95% CI)	(95% CI)	(95% CI)	(95% CI)	(95% CI)
Hypsarrhythmia	Yes	13.5% (5)	0% (0)	0.38 (0.14, 0.68)	1.00 (0.86, 1.00)	1.00 (0.48, 1.00)	0.75 (0.57, 0.89)	0.62 (0.40, 0.95)
Hypsarrhythmia	No	21.6% (8)	64.9% (24)	0.38 (0.14, 0.68)	1.00 (0.86, 1.00)	1.00 (0.48, 1.00)	0.75 (0.57, 0.89)	0.62 (0.40, 0.95)
Electroclinical spasms	Yes	24.3% (9)	0% (0)	0.69 (0.39, 0.91)	1.00 (0.86, 1.00)	1.00 (0.66, 1.00)	0.86 (0.67, 0.96)	0.31 (0.14, 0.70)
Electroclinical spasms	No	10.8% (4)	64.9% (24)	0.69 (0.39, 0.91)	1.00 (0.86, 1.00)	1.00 (0.66, 1.00)	0.86 (0.67, 0.96)	0.31 (0.14, 0.70)
Positive EEG ^a for IS features	Yes	29.7% (11)	0% (0)	0.85 (0.55, 0.98)	1.00 (0.86, 1.00)	1.00 (0.72, 1.00)	0.92 (0.75, 0.99)	0.15 (0.04, 0.55)
Positive EEG ^a for IS features	No	5.4% (2)	64.9% (24)	0.85 (0.55, 0.98)	1.00 (0.86, 1.00)	1.00 (0.72, 1.00)	0.92 (0.75, 0.99)	0.15 (0.04, 0.55)
Positive EEG ^a and 2‐week clinical assessment	Yes	35.1% (13)	0%. (0)	1.00 (0.75, 1.00)	1.00 (0.86, 1.00)	1.00 (0.75, 1.00)	1.00 (0.86, 1.00)	0.00 (0.00, 0.00)
Positive EEG ^a and 2‐week clinical assessment	No	0% (0)	64.9% (24)	1.00 (0.75, 1.00)	1.00 (0.86, 1.00)	1.00 (0.75, 1.00)	1.00 (0.86, 1.00)	0.00 (0.00, 0.00)
Positive EEG ^a during 1st hour	Yes	21.6% (8)	0% (0)	0.62 (0.32, 0.86)	1.00 (0.86, 1.00)	1.00 (0.63, 1.00)	0.83 (0.64, 0.94)	0.38 (0.19, 0.76)
Positive EEG ^a during 1st hour	No	13.5% (5)	64.9% (24)	0.62 (0.32, 0.86)	1.00 (0.86, 1.00)	1.00 (0.63, 1.00)	0.83 (0.64, 0.94)	0.38 (0.19, 0.76)

Abbreviations: EEG, electroencephalogram; IS, infantile spasms; NLR, negative likelihood ratio; NPV, negative predictive value; PPV, positive predictive value.

^{^a}

Positive EEG = presence of hypsarrhythmia, modified hypsarrhythmia, and/or electroclinical spasms.