TABLE 6.
Brain regions showing significant gray matter volume SPC changes (increase/decrease) in voxel-based analysis between the meditation and non-meditation groups corrected for multiple comparisons, age, gender, and education in both hemispheres.
| Brain region (TalX, TalY, TalZ) | Size (mm2) | P-value |
|
| ||
| Left Hemisphere | ||
| SPC for Meditation > Non-meditation | ||
| Lateral occipital (−42.6, −75.9, 4.5) | 281.47 | <0.00021 |
| Caudal middle frontal (−32.4, 13.3, 47.6) | 225.47 | <0.0025 |
| Rostral middle frontal (−44.1, 26.9, 28.1) | 136.1 | <0.000073 |
| Superior parietal (−25.2, −57.3, 51.6) | 127.19 | <0.0010 |
| Superior frontal (−6.9, 26.5, 45.2) | 90.77 | <0.0013 |
| Banks of superior temporal sulcus (−62, −34.3, 4.6) | 87.22 | <0.0027 |
| Medial orbitofrontal (−9.1, 47.8, −8.8) | 64.64 | <0.0020 |
| Superior parietal (−15.1, −68.2, 47.2) | 53.04 | <0.0011 |
| Caudal middle frontal (−32.2, 23.8, 42) | 48.32 | <0.0040 |
|
| ||
| Right Hemisphere | ||
|
| ||
| SPC for Meditation > Non-meditation | ||
| Superior frontal (18.6, 14, 60.2) | 341.4 | <0.0002 |
| Lateral orbitofrontal (26.7, 18.1, −20.5) | 70.23 | <0.0027 |
| Superior frontal (10, −3.7, 67) | 66.56 | <0.0030 |
| Rostral middle frontal (44.7, 31.8, 21.6) | 62.13 | <0.0014 |
| Lateral orbitofrontal (13.2, 31.7, −17.8) | 50.7 | <0.0005 |
TalX, Y, and Z represent Talairach coordinates X, Y, and Z. Table includes only the regions which had cluster size greater than 50 mm2 and corresponding significance (p-value) less than 0.05. None of the brain regions showed significantly decreased gray matter volume in the meditation group. The medial orbitofrontal region showed negative SPC values of gray matter volume for both groups but significantly less negative in the meditation group compared to the non-meditation group.