Table 2.
Weight loss vs. adverse events leading to medication discontinuation comparison of GLP-1 agonist/analog drug-dosage groups by network meta-analysis
| Mean difference (95% CrI) of weight loss | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Relative risk (95% CrI) of discontinuation due to adverse events | Placebo | -0.41 (-1.89 to 1.06) | -1.43 (-2.70 to -0.15) | -1.77 (-2.75 to -0.79) | -2.19 (-5.02 to 0.65) | -3.15 (-4.99 to -1.31) | -2.61 (-3.38 to -1.84) | -4.19 (-5.26 to -3.13) | -0.72 (-2.89 to 1.46) | -4.49 (-5.55 to -3.43) | -9.72 (-11.34 to -8.11) | -2.79 (-4.42 to -1.17) | -1.71 (-4.80 to 1.39) |
| 0.81 (0.26 to 2.46) | Dulaglu-tide <1.5mg | -1.01 (-2.49 to 0.46) | -1.36 (-3.14 to 0.41) | -1.78 (-4.97 to 1.42) | -2.74 (-5.10 to -0.38) | -2.20 (-3.86 to -0.53) | -3.78 (-5.60 to -1.96) | -0.31 (-2.93 to 2.32) | -4.08 (-5.89 to -2.26) | -9.31 (-11.50 to -7.13) | -2.38 (-4.58 to -0.19) | -1.29 (-4.72 to 2.13) | |
| 2.07 (0.84 to 5.11) | 2.57 (0.98 to 6.71) | Dulaglu-tide ≥1.5 mg | -0.35 (-1.95 to 1.26) | -0.76 (-3.87 to 2.35) | -1.72 (-3.96 to 0.51) | -1.18 (-2.67 to 0.30) | -2.77 (-4.42 to -1.11) | 0.71 (-1.81 to 3.23) | -3.06 (-4.72 to -1.41) | -8.30 (-10.35 to -6.24) | -1.37 (-3.43 to 0.69) | -0.28 (-3.63 to 3.07) | |
| 2.05 (1.21 to 3.48) | 2.54 (0.74 to 8.75) | 0.99 (0.35 to 2.82) | Exana-tide IR | -0.41 (-3.41 to 2.59) | -1.37 (-3.46 to 0.71) | -0.83 (-2.08 to 0.41) | -2.42 (-3.87 to -0.97) | 1.06 (-1.32 to 3.44) | -2.72 (-4.16 to -1.27) | -7.95 (-9.84 to -6.06) | -1.02 (-2.92 to 0.87) | 0.07 (-3.18 to 3.31) | |
| 0.29 (0.02 to 3.58) | 0.36 (0.02 to 5.63) | 0.14 (0.01 to 2.02) | 0.14 (0.01 to 1.85) | Exana-tide ER | -0.96 (-4.34 to 2.42) | -0.42 (-3.36 to 2.51) | -2.01 (-5.04 to 1.02) | 1.47 (-2.10 to 5.04) | -2.30 (-5.33 to 0.72) | -7.54 (-10.80 to -4.27) | -0.61 (-3.87 to 2.66) | 0.48 (-3.72 to 4.68) | |
| 1.91 (0.80 to 4.53) | 2.36 (0.57 to 9.73) | 0.92 (0.26 to 3.22) | 0.93 (0.34 to 2.57) | 6.60 (0.46 to 94.62) | Efpegla-natide | 0.54 (-1.45 to 2.53) | -1.05 (-3.17 to 1.08) | 2.43 (-0.41 to 5.28) | -1.34 (-3.46 to 0.78) | -6.57 (-9.02 to -4.13) | 0.35 (-2.10 to 2.81) | 1.44 (-2.16 to 5.04) | |
| 1.93 (1.29 to 2.89) | 2.40 (0.73 to 7.89) | 0.93 (0.35 to 2.50) | 0.94 (0.49 to 1.84) | 6.70 (0.52 to 85.79) | 1.02 (0.39 to 2.64) | Liraglu-tide ≤ 1.8mg | -1.59 (-2.82 to -0.35) | 1.89 (-0.41 to 4.19) | -1.88 (-3.14 to -0.63) | -7.11 (-8.89 to -5.33) | -0.19 (-1.91 to 1.54) | 0.90 (-2.29 to 4.09) | |
| 2.31 (1.53 to 3.49) | 2.87 (0.87 to 9.44) | 1.12 (0.41 to 3.01) | 1.13 (0.58 to 2.21) | 8.00 (0.62 to 102.67) | 1.21 (0.46 to 3.17) | 1.19 (0.72 to 1.99) | Liraglu -tide >1.8mg | 3.48 (1.06 to 5.90) | -0.30 (-1.74 to 1.15) | -5.53 (-7.45 to -3.60) | 1.40 (-0.52 to 3.32) | 2.49 (-0.78 to 5.76) | |
| 1.80 (0.73 to 4.44) | 2.23 (0.53 to 9.40) | 0.87 (0.24 to 3.11) | 0.88 (0.31 to 2.51) | 6.22 (0.43 to 90.35) | 0.94 (0.27 to 3.30) | 0.93 (0.34 to 2.50) | 0.78 (0.29 to 2.10) | Lixise-natide | -3.77 (-6.19 to -1.36) | -9.01 (-11.71 to -6.30) | -2.08 (-4.79 to 0.63) | -0.99 (-4.77 to 2.79) | |
| 2.12 (1.32 to 3.41) | 2.63 (0.78 to 8.88) | 1.02 (0.37 to 2.83) | 1.04 (0.51 to 2.11) | 7.34 (0.57 to 95.22) | 1.11 (0.41 to 2.99) | 1.10 (0.62 to 1.93) | 0.92 (0.51 to 1.64) | 1.18 (0.43 to 3.28) | Sema-glutide SQ <2.4mg | -5.23 (-7.06 to -3.41) | 1.69 (-0.13 to 3.52) | 2.78 (-0.49 to 6.05) | |
| 2.09 (1.07 to 4.09) | 2.60 (0.71 to 9.55) | 1.01 (0.33 to 3.12) | 1.02 (0.44 to 2.40) | 7.25 (0.54 to 98.14) | 1.10 (0.37 to 3.28) | 1.08 (0.50 to 2.35) | 0.91 (0.42 to 1.97) | 1.17 (0.38 to 3.60) | 0.99 (0.47 to 2.09) | Sema-glutide SQ 2.4mg | 6.93 (4.66 to 9.20) | 8.02 (4.53 to 11.51) | |
| 1.45 (0.72 to 2.95) | 1.80 (0.48 to 6.78) | 0.70 (0.22 to 2.21) | 0.71 (0.29 to 1.72) | 5.04 (0.37 to 68.92) | 0.76 (0.25 to 2.34) | 0.75 (0.35 to 1.62) | 0.63 (0.28 to 1.40) | 0.81 (0.26 to 2.56) | 0.69 (0.33 to 1.45) | 0.70 (0.27 to 1.80) | Sema-glutide Oral | 1.09 (-2.40 to 4.58) | |
| 3.86 (1.02 to 14.68) | 4.79 (0.84 to 27.35) | 1.87 (0.37 to 9.36) | 1.89 (0.45 to 7.94) | 13.38 (0.77 to 231.40) | 2.03 (0.41 to 9.96) | 2.00 (0.50 to 8.06) | 1.67 (0.41 to 6.76) | 2.15 (0.43 to 10.81) | 1.82 (0.44 to 7.52) | 1.85 (0.41 to 8.22) | 2.66 (0.59 to 12.04) | Taspo-glutide | |