. 2021 Oct 31;297(6):101374. doi: 10.1016/j.jbc.2021.101374

Table 1.

Metal ions interchangeability within SODs

Kingdom/order	Species	SOD	Native Me cofactor	Active site's Me replacement	Dismutation enzymatic activity	Cambialism	Reference
Bacteria/Bacillales	Staphylococcus aureus	SodA	Mn²⁺	—	Active	—	(141)
		SodM^a	Mn²⁺/Fe²⁺^a	Mn²⁺ or Fe²⁺^a	Active^a	Yes^a	(141)^a
		smSod^a	Mn²⁺^a	Mn²⁺ or Fe²⁺^a	Active^a	Yes^a	(257, 258)^a
		stSod^a	Mn²⁺^a	Mn²⁺ or Fe²⁺^a	Active^a	Yes^a	(258, 259)^a
Bacteria/Enterobacterales	Escherichia coli	SodA	Mn²⁺	—	Active	—	(125, 260)
		SodA	Mn²⁺	Fe²⁺	Gain of function: peroxidase^c	No	(141)
		Mutant SodA^G165T^a	—^a	Fe²⁺^a	Active^a	Yes^a	(139)^a
		SodA	Mn²⁺	Mn²⁺, Fe²⁺ hybrid^b	Partially active^b	No^b	(261)^b
		SodB	Fe²⁺	—	Active	—	(125)
		SodB	Fe²⁺	Mn²⁺	Inactive	No	(125)
		Mutant SodB^T165G^a	—^a	Mn²⁺^a	Active^a	Yes^a	(137)^a
		SodC	Cu²⁺Zn²⁺	—	Active	—	(262)
Bacteria/Streptomycetales	Streptomyces coelicolor	SodN	Ni²⁺	Ni²⁺	Active	—	(196, 197)
				Fe²⁺	Inactive	No	(197)
				Zn²⁺	Inactive	No	(197)
				Fe²⁺, Zn²⁺ hybrid^b	Active^b	No^b	(196)^b
Bacteria/Bacteroidales	Porphyromonas gingivalis	pgSod^a	Fe²⁺^a	Mn²⁺ or Fe²⁺^a	Active^a	Yes^a	(258)^a
Bacteria/Actinobacteria	Propionibacterium shermanii	psSod^a	Fe²⁺^a	Mn²⁺ or Fe²⁺^a	Active^a	Yes^a	(258)^a
Archaea/Sulfolobales	Acidianus ambivalens	FeSod	Fe²⁺	—	Active	—	(263)
				Co²⁺	Inactive	No	(263)
				Ni²⁺	Inactive	No	(263)
				Mn²⁺	Inactive	No	(263)
Fungi/Saccharomycetales	Saccharomyces cerevisiae	Sod1	Cu²⁺Zn²⁺	—	Active	—	(264)
		Sod2	Mn²⁺	—	Active	—	(265)
		Sod2	Mn²⁺	Fe²⁺	Inactive	No	(136, 266)
Animalia/Mammalia	Mammals	SOD1	Cu²⁺Zn²⁺	—	Active	—	(190)
		SOD1	Cu²⁺Zn²⁺	Cu²⁺Cu²⁺	Inactive	No	(189)
		SOD2	Mn²⁺	—	Active	—	(120, 267)
		SOD2	Mn²⁺	Fe²⁺	Gain of function: peroxidase^c	No	(133)
		SOD3	Cu²⁺Zn²⁺	—	Active	—	(118, 267, 268, 269)
Plantae/laurales	Cinnamomum camphora	FeSOD^a	Fe²⁺^a	Mn²⁺ or Fe²⁺^a	Active^a	Yes^a	(270)^a

Highlight SODs with cambialistic properties.

Highlight hybrid SODs, whereby two different metal ions (indicated in the table) occupy two distinct enzyme dimer's subunits.

Highlight SODs with peroxidase activity gained upon metal ion replacement.