Figure 1.

An effective application mode of USCs in skin defect repair. Pretreatment can improve the performance of USCs. The secretions of USCs have therapeutic effects. USCs cultured with the membrane materials may show a synergistic effect. A variety of cellular strategies may impact on bioactivities through different pathways, and ultimately act on the effector cells to repair the skin defect. PCL/GT polycaprolactone/gelatin, S-BC surface-structured bacterial cellulose, SIS porcine small intestine submucosa