Table 2.
Patient, Tumor, and Treatment Characteristics
| Study | Primary Tumor Site (%) | Single BM (%) | GTR (%) | Adjuvant Radiation (%) | Neo-adjuvant Radiation (%) | Systemic Therapy (%) | Male Patients (%) | Median Age at Diagnosis | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Breast | Lung | Gastro-intestinal | Melanoma | Kidney | Other | ||||||||
| Ahn et al (2012)17 | 25 (10) | 164 (68) | – | – | – | 53 (22) | 164 (68) | – | 143 (59) | 0 | 117 (48) | – | 61 |
| Atalar et al. (2013)18 | 27 (15) | 76 (43) | 18 (10) | 24 (14) | – | 30 (17) | – | 160 (91) | 165 (100) | 0 | 24 (14) | 67 (38) | 60 |
| Ojerholm et al. (2014)27 | 12 (13) | 39 (43) | 10 (11) | 13 (14) | 6 (7) | 13 (12) | – | 79 (82) | 91 (100) | 0 | – | 36 (40) | 60 |
| Hsieh et al. (2015)21 | 30 (14) | 108 (51) | – | 22 (10) | – | 45 (22) | 125 (59) | – | 212 (100) | 0 | – | 90 (42) | 58 |
| Patel et al. (2016)28 | 30 (16.7) | 72 (40) | – | 34 (18.8) | – | 44 (24.4) | 121 (67.2) | 142 (78.9) | 180 (100) | 66 (36.7) | – | 77 (40) | 60 |
| Keller et al. (2017)24 | 20 (11.1) | 82 (45.3) | 18 (9.9) | 16 (8.8) | 18 (9.9) | 14 (15) | 138 (73) | 178 (94.2) | 181 (100) | 0 | 7 (3.8) | 100 (55) | 61 |
| Press et al. (2019)30 | 21 (15.7) | 64 (47.8) | – | 25 (18.7) | – | 24 (11.2) | 38 (28.4) | 96 (71.6) | 134 (100) | 0 | 30 (22.6) | 55 (41) | 59 |
| Foreman et al. (2018)20 | 11 (12.1) | 39 (42.9) | 3 (3.3) | 17 (18.7) | 8 (8.8) | 10 (14.3) | 64 (70.3) | 70 (76.9) | 91 (100) | 0 | – | 41 (45) | – |
| DePaoli et al. (2019)19 | 2 (4) | 32 (64) | 4 (8) | 7 (14) | 4 (8) | 1 (2) | 32 (64) | – | 50 (100) | 0 | – | 23 (46) | – |
| Soliman et al. (2019)31 | 25 (21) | 56 (46) | 7 (6) | 9 (7) | 10 (8) | 15 (12) | 89 (73) | 122 (89)a | 122 (100)a | 0 | 37 (30) | 43 (35) | – |
| Nguyen et al. (2020)26 | 30 (21.9) | 60 (43.8) | 11 (8.0) | 9 (6.6) | 11 (8.0) | 16 (11.7) | 90 (73.2) | 123 (90.4) | 123 (100) | 0 | 38 (30.9) | – | 62 |
| Shi et al. (2020)33 | 78 (18) | 52 (34) | 53 (12) | 50 (11) | 27 (6) | 82 (19) | – | 447 (90)b | 442 (100)b | 75 (17) | 269 (54) | 214 (48) | 62 |
| Teyateeti et al. (2020)32 | 9 (15) | 34 (55) | – | 9 (15) | 5 (8) | 5 (8) | 39 (63) | – | 62 (100) | 0 | – | 24 (39) | 66 |
Abbreviations: GTR, gross total resection; BM, brain metastases.
a137 BM in total in 122 patients.
b501 BM in total in 442 patients.