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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Acta Physiol (Oxf). 2020 Apr 11;229(4):e13471. doi: 10.1111/apha.13471

Figure 3. Lin-GLY effects depend on guinea pig KCNE1 residues.

Figure 3.

(a) Concentration-response relationship for the ability of DHA-GLY and Lin-GLY to shift the voltage dependence of activation (i.e. ΔV50) of hKCNQ1/hKCNE1 channels expressed in Xenopus oocytes. Data shown as mean ± sem, n = 8. Statistics denote Student’s t-test for the effect at 20 μM. (b) Sequence alignment of human KCNE1 (hKCNE1), guinea pig KCNE1 (gpKCNE1), and the constructed guinea pig like KCNE1 (gplKCNE1) subunits. Deviating residues in the extracellular terminal are marked in red. The transmembrane (TM) region is indicated by the dashed box. (c) Concentration-response relationship of the ability of DHA-GLY and Lin-GLY to shift V50 of hKCNQ1/gplKCNE1 channels expressed in Xenopus oocytes. Data shown as mean ± sem, n = 8–11. Statistics denote Student’s t-test for the effect at 20 μM.