Table I.
Summary of PUFA effect on QT-intervals and APD90 in ex-vivo guinea pig hearts.
| Compound | Baseline (ms) | E4031 0.03 μM (ms) | ΔQT/APD90, compared with baseline (ms) | PUFA (ms) | ΔQT/APD90, compared with E4031 (ms) | ΔQT/APD90, compared with baseline (ms) | n | |
|---|---|---|---|---|---|---|---|---|
| DHA-GLY (10 μM) | QT | 132.9 ± 3.2 | 151.5 ± 4.1 | +18.6 ± 1.9 (P < 0.001) | 135.4 ± 3.7 | −16.2 ± 2.4 (P < 0.01) | +2.4 ± 1.7 (P = 0.4) | 6 |
| APD90 | 118.1 ± 1.9 | 133.8 ± 2.7 | +15.8 ± 1.7 (P < 0.001) | 110.6 ± 4.1 | −23.2 ± 3.6 (P < 0.01) | −7.4 ± 3.2 (P = 0.13) | 6 | |
| DHA (10 μM) | QT | 135.7 ± 1.5 | 156.0 ± 1.5 | +20.3 ± 2.7 (P < 0.01) | 145.2 ± 4.3 | −10.8 ± 1.4 (P < 0.01) | +9.6 ± 3.1 (P = 0.06) | 6 |
| APD90 | 115.5 ± 1.4 | 132.3 ± 3.0 | +16.8 ± 2.3 (P < 0.01) | 115.9 ± 3.7 | −16.4 ± 1.2 (P < 0.001) | +0.3 ± 3.2 (P = 0.99) | 6 | |
| Lin-GLY (10 μM) | QT | 134.6 ± 1.7 | 152.7 ± 1.0 | +18.1 ± 1.8 (P < 0.01) | 148.4 ± 1.3 | −4.3 ± 1.3 (P ≤ 0.05) | +13.8 ± 1.1 (P ≤ 0.05) | 5 |
| APD90 | 121.4 ± 0.7 | 141.0 ± 1.7 | +19.6 ± 1.7 (P < 0.001) | 132.4 ± 2.7 | −8.6 ± 1.5 (P ≤ 0.05) | +11.0 ± 3.0 (P ≤ 0.05) | 5 | |
| N-AT (30 μM) | QT | 133.0 ± 1.9 | 149.2 ± 2.3 | +16.2 ± 3.1 (P < 0.01) | 132.7 ± 3.2 | −16.4 ± 2.6 (P < 0.01) | −0.3 ± 2.7 (P = 0.7) | 6 |
| APD90 | 115.4 ± 2.9 | 131.3 ± 2.0 | +15.9 ± 2.5 (P < 0.01) | 112.3 ± 3.4 | −19.0 ± 3.0 (P < 0.01) | −3.1 ± 1.8 (P = 0.29) | 6 |
QT/APD90 determined during pacing at 250 BPM as described in Methods. Data shown as mean ± sem. Statistics denote repeated measures one-way ANOVA followed by Tukeýs multiple comparison test.