. Author manuscript; available in PMC: 2021 Dec 1.

Published in final edited form as: Acta Physiol (Oxf). 2020 Apr 11;229(4):e13471. doi: 10.1111/apha.13471

Table II.

Summary of DHA-GLY effect on cardiovascular parameters in ex-vivo guinea pig hearts.

Parameter	Baseline	E4031 0.03 μM	Δ_E4031, compared with baseline	DHA-GLY 10 μM	Δ_DHA-GLY, compared with E4031	Δ_DHA-GLY, compared with baseline	n

PR interval	58.8 ± 3.6^†	61.2 ± 4.2^†	+2.4 ± 0.9^† (P = 0.09)	69.4 ± 4.2^†	+8.2 ± 2.2^† (P ≤ 0.05)	+10.6 ± 2.7^† (P ≤ 0.05)	6
QRS duration	18.8 ± 0.6^†	18.8 ± 0.6^†	+0.1 ± 0.2^† (P = 0.9)	19.1 ± 0.6^†	+ 0.3 ± 0.3^† (P = 0.7)	+ 0.4 ± 0.3^† (P = 0.5)	6
Coronary flow	16.2 ± 2.0^‡	14.3 ± 2.0^‡	−1.8 ± 0.3^‡ (P < 0.01)	12.2 ± 1.8^‡	−2.0 ± 2.3^‡ (P = 0.7)	−3.9 ± 2.2^‡ (P = 0.3)	6

Parameters determined during pacing at 250 BPM as described in Methods. Data shown as mean ± sem. Statistics denote repeated measures one-way ANOVA followed by Tukeýs multiple comparison test.

^†

denotes ms.

^‡

denotes ml/min.