Table III.

Changes in PR interval, QRS duration and QT interval in in-vivo guinea pig experiments.

Treatment	ΔPR (ms)		ΔQRS (ms)		ΔQT (ms)		n
TMC (vehicle)	−1.0 ± 2.3		−0.9 ± 1.1		+1.2 ± 1.6		5
DHA-GLY (10 mg/ml)	+9.2 ± 3.0	(P = 0.03†)	+0.2 ± 0.8	(P = 0.561†)	−17.3 ± 2.8	(P = 0.001†)	5

Parameters determined during pacing at 300 BPM as described in Methods. TMC denotes time-matched controls receiving vehicle infusion. Δ-values refers to the absolute changes (test-baseline) in PR interval, QRS duration and QT interval between test values and baseline values. Test values (for vehicle or DHA-GLY) were determined after 30 minutes of infusion (time = +30 min). Baseline values were determined 5 minutes prior to DHA-GLY/vehicle infusion (time = −5 min). Data shown as mean ± sem.

^†P-values refer to the comparison of Δ-values between TMC and DHA-GLY groups using unpaired Student’s-t test..