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Differences between the BBB and BTB. (A) Endothelial cells in a healthy brain are held together by tight junction proteins and prevent paracellular transport. The endothelial cells are surrounded by a basement membrane embedded with pericytes and astrocytic foot processes along the outside. (B) The BTB is leakier than the BBB due to lack of tight junction proteins and decreased association of astrocytic end-foot processes and pericytes with the barrier.
