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. 2021 Dec 1;18(185):20210464. doi: 10.1098/rsif.2021.0464

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© 2021 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 5. — Comparing model predictions with reported in vivo effects of S1P₁r downregulation on TC activation. (a) Simulation results (n = 10) with and without S1P₁r downregulation (±SP regulation) showed total activated TC number reduced by 60%, 72% and 81% (mean±s.e.m.) at V_max = 1.2, 1.5 and 2. (b) Pre-activated TCs over-expressing S1P₁r (−SP regulation) were transferred into mice. Retention of activated TCs 15 h later fell by 90% compared with transferred wild-type TCs (SP+ regulation). Adapted from Lo et al. [24]. (c) In mice with constitutive S1P₁r expression, activated TC number in LNs 24 h post-immunization dropped by 40%. Adapted from Gräler et al. [49].