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. 2021 Dec 1;18(185):20210464. doi: 10.1098/rsif.2021.0464

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© 2021 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 6. — Changes in TC response in the paracortex when varying swelling. Between V_max = 1 and 2.8, (a) total activated TCs doubled and positively correlated with V_max (R² = 0.96, p = 1.07 × 10⁻⁶), (b) total effector TCs decreased 0.3-fold, negatively correlating with V_max (R² = 0.86, p = 1.23 × 10⁻⁴), (c) total cognate CD8⁺ TCs negatively correlated with V_max (R² = 0.855, p = 1.28 × 10⁻⁴), and (d) total cognate CD4⁺ TCs that exited increased 1.3-fold, positively correlating with V_max (R² = 0.76, p = 0.001). (e,f) Peak entry and exit rate increased proportionally to V_max. Results are the mean of n ≥ 7 simulations with s.e.m. displayed.