Figure 8.

Varying the pattern of paracortical swelling. (a) The paracortex swells earlier and for a longer duration with a low T_mid. (b) Increased swelling aided TC activation. (c) With a lower T_mid, as swelling increased, the number of effector TCs that exited decreased. (d) Further simulations varying T_mid confirmed that, at a large swelling (V_max = 2.5), delayed swelling with a higher T_mid resulted in more total effectors TCs (R² = 0.97, p = 3 × 10⁻⁴). (e) This effect was due to altered CD8⁺ TC number as (f) CD4⁺ TC number increased with V_max but was unaffected by varying T_mid.