Table 2.

Parameters, values, and units for the variables in the partial and ordinary differential equations found in the simulation (6, 7).

Parameter	Value	Unit	Reference
kMTNF	8.65	hr -1	Brady et al., 2016
kTNF	200	day –1	Brady et al., 2016
kTNFM	1.5	$\frac{relative cytokine concentration}{day·\# of cells}$	Brady et al., 2016
k6	4.64	day -1	Brady et al., 2016
k6M	0.01	$\frac{relative cytokine concentration}{day·\# of cells}$	Brady et al., 2016
k6TNF	0.81	$\frac{relative cytokine concentration}{day·\# of cells}$	Brady et al., 2016
k8	0.464	day -1	Brady et al., 2016
k8M	0.056	$\frac{relative cytokine concentration}{day·\# of cells}$	Brady et al., 2016
k8TNF	0.56	$\frac{relative cytokine concentration}{day·\# of cells}$	Brady et al., 2016
k10	1.1	day -1	Brady et al., 2016
k10M	0.19	$\frac{relative cytokine concentration}{day·\# of cells}$	Brady et al., 2016
k106	0.0191	$\frac{relative cytokine concentration}{day·\# of cells}$	Brady et al., 2016
qTNF	0.14	relative concentration	Brady et al., 2016
qIL6	0.6	relative concentration	Brady et al., 2016
qIL8	0.2	relative concentration	Brady et al., 2016
qIL10	0.15	relative concentration	Brady et al., 2016
ηTNF6	560	relative concentration	Brady et al., 2016
ηTNF10	17.4	relative concentration	Brady et al., 2016
η610	34.8	relative concentration	Brady et al., 2016
η66	560	relative concentration	Brady et al., 2016
η6TNF	185	relative concentration	Brady et al., 2016
η810	17.4	relative concentration	Brady et al., 2016
η8TNF	185	relative concentration	Brady et al., 2016
η106	560	relative concentration	Brady et al., 2016
h106	3.68	dimentionless	Brady et al., 2016
h6TNF	2	dimentionless	Brady et al., 2016
h66	1	dimentionless	Brady et al., 2016
h610	4	dimentionless	Brady et al., 2016
h8TNF	3	dimentionless	Brady et al., 2016
h810	1.5	dimentionless	Brady et al., 2016
hTNF10	3	dimentionless	Brady et al., 2016
hTNF6	2	dimentionless	Brady et al., 2016
DA	3.7·10-15	$\frac{m{m}^3}{day}$	Quintela et al., 2014
DMR	4.32·10-2	$\frac{m{m}^3}{day}$	Quintela et al., 2014
DMA	0.3	$\frac{m{m}^3}{day}$	Quintela et al., 2014
βA	2.0	day -1	Quintela et al., 2014
kA	50.0	$\frac{cell}{m{m}^3}$	Quintela et al., 2014
μA	0.1	day –1	Quintela et al., 2014
μMR	0.033	day -1	Quintela et al., 2014
μMA	0.07	day -1	Quintela et al., 2014
γMA	8.3·10-2	$\frac{m{m}^3}{cell·day}$	Quintela et al., 2014
λMR	5.98·10-3	$\frac{m{m}^3}{cell·day}$	Quintela et al., 2014
λMA	5.98·10-2	$\frac{m{m}^3}{cell·day}$	Quintela et al., 2014
λAFMR	1.66·10-3	$\frac{m{m}^6}{cel{l}^2·day}$	Quintela et al., 2014
λAFMA	7.14·10-2	$\frac{m{m}^6}{cel{l}^2·day}$	Quintela et al., 2014
αMA	10-3	day -1	Quintela et al., 2014
αMR	4.0	day -1	Quintela et al., 2014

These parameters can be adjusted to depict in vivo conditions.