Table 4.
List of the differentially expressed proteins identified in the myocardium from patients with CCC, IC and DCM when compared to individuals without cardiomyopathies.
| a) Differentially Expressed Proteins Only in CCC patients | Total Spots‡ | CCC/N | IC/N | DCM/N | |||||
|---|---|---|---|---|---|---|---|---|---|
| Entry name* | Protein names† | Function | ↑↓ | S§ | ↑↓ | S§ | ↑↓ | S§ | |
| ARP3 | Actin-like protein 3 | 1. Structural and Contractile Proteins | 1 | ↑ | 1 | ||||
| ENOA | Alpha-enolase (Non- neural enolase) | 2.1. Glycolysis | 6 | ↑ | 1 | ||||
| G3P | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) | 2.1. Glycolysis | 7 | ↑ | 2 | ||||
| MCCB | Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial | 2.6. Other Metabolic Processes | 1 | ↑ | 1 | ||||
| CATA | Catalase | 3. Stress Response and Apoptosis | 2 | ↑ | 2 | ||||
| HSPB7 | Heat shock protein beta-7 | 3. Stress Response and Apoptosis | 1 | ↑ | 1 | ||||
| TR10B | Tumor necrosis factor receptor superfamily member 10B | 3. Stress Response and Apoptosis | 1 | ↑ | 1 | ||||
| LEG3 | Galectin-3 | 4. Immune Response | 1 | ↑ | 1 | ||||
| BLK | Tyrosine-protein kinase BLK | 5. Cell Signaling | 1 | ↑ | 1 | ||||
| PSME1 | Proteasome activator complex subunit 1 (Interferon gamma up-regulated I-5111 protein) | 8. Proteasome-Ubiquitin Process/Immune response | 1 | ↑ | 1 | ||||
| APOA1 | Apolipoprotein A-I precursor | 9. Other Functions | 2 | ↑ | 1 | ||||
| F90AM | Putative protein FAM90A22 | 9. Other Functions | 1 | ↑ | 1 | ||||
| ACTA | Actin, aortic smooth muscle (Alpha-actin-2) |
1. Structural and Contractile Proteins | 1 | ↓ | 1 | ||||
| MYL4 | Myosin light polypeptide 4 (Myosin light chain 1, embryonic muscle/atrial isoform) | 1. Structural and Contractile Proteins | 1 | ↓ | 1 | ||||
| STML2 | Stomatin-like protein 2 | 1. Structural and Contractile Proteins | 1 | ↓ | 1 | ||||
| TPM1 | Tropomyosin-1 alpha chain | 1. Structural and Contractile Proteins | 1 | ↓ | 1 | ||||
| ACADVL | Very long-chain specific acyl-CoA dehydrogenase, mitochondrial | 2.2. Lipid Metabolism/ß-Oxidation | 5 | ↓ | 3 | ||||
| HCDH | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 2.2. Lipid Metabolism/ß-Oxidation | 4 | ↓ | 4 | ||||
| THIM | 3-ketoacyl-CoA thiolase, mitochondrial | 2.2. Lipid Metabolism/ß-Oxidation | 2 | ↓ | 1 | ||||
| MDHM | Malate dehydrogenase, mitochondrial | 2.3. Tricarboxylic Acid Cycle | 4 | ↓ | 3 | ||||
| NDUS1 | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | 2.4. Oxidative Phosphorylation and Electron Transport | 3 | ↓ | 2 | ||||
| ROA2 | Heterogeneous nuclear ribonucleoproteins A2/B1 | 2.6. Other Metabolic Processes | 2 | ↓ | 1 | ||||
| HSPB1 | Heat-shock protein beta-1 (Heat shock 27 kDa protein) | 3. Stress Response and Apoptosis | 3 | ↓ | 1 | ||||
| KELL | Kell blood group glycoprotein | 9. Other Functions | 1 | ↓ | 1 | ||||
| SKT | Sickle tail protein homolog | 9. Other Functions | 1 | ↓ | 1 | ||||
| b) Differentially Expressed Proteins Only in IC patients | Total Spots‡ | CCC/N | IC/N | DCM/N | |||||
| Entry name* | Protein names† | Function | ↑↓ | S§ | ↑↓ | S§ | ↑↓ | S§ | |
| ACON | Aconitate hydratase, mitochondrial (Aconitase) | 2.3. Tricarboxylic Acid Cycle | 8 | ↑ | 3 | ||||
| KI26A | Kinesin-like protein KIF26A | 1. Structural and Contractile Proteins | 1 | ↓ | 1 | ||||
| W19L5 | Putative WBSCR19-like protein 5 | 9. Other Functions | 1 | ↓ | 1 | ||||
| c) Differentially Expressed Proteins Only in DCM patients | Total Spots‡ | CCC/N | IC/N | DCM/N | |||||
| Entry name* | Protein names† | Function | ↑↓ | S§ | ↑↓ | S§ | ↑↓ | S§ | |
| PDLI1 | PDZ and LIM domain protein 1 | 1. Structural and Contractile Proteins | 1 | ↑ | 1 | ||||
| VINC | Vinculin (Metavinculin) | 1. Structural and Contractile Proteins | 2 | ↑ | 2 | ||||
| ODO2 | 2-oxoglutarate dehydrogenase E2 component, mitochondrial | 2.3. Tricarboxylic Acid Cycle | 2 | ↑ | 1 | ||||
| COQ9 | Ubiquinone biosynthesis protein COQ9, mitochondrial | 2.6. Other Metabolic Processes | 1 | ↑ | 1 | ||||
| HSP7C | Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8). | 3. Stress Response and Apoptosis | 2 | ↑ | 2 | ||||
| SAMP | Serum amyloid P-component precursor | 3. Stress Response and Apoptosis | 1 | ↑ | 1 | ||||
| ZN799 | Zinc finger protein 799 | 6. Transcription and Translation Processes | 1 | ↑ | 1 | ||||
| IFIT5 | Interferon-induced protein with tetratricopeptide repeats 5 | 9. Other Functions | 1 | ↑ | 1 | ||||
| CAZA2 | F-actin capping protein subunit alpha-2 (CapZ alpha-2) | 1. Structural and Contractile Proteins | 1 | ↓ | 1 | ||||
| MYOZ2 | Myozenin-2 | 1. Structural and Contractile Proteins | 3 | ↓ | 1 | ||||
| TPIS | Triosephosphate isomerase | 2.1. Glycolysis | 3 | ↓ | 1 | ||||
| NDUAD | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 | 2.4. Oxidative Phosphorylation and Electron Transport | 1 | ↓ | 1 | ||||
| GSTM2 | Glutathione S-transferase Mu 2 | 2.6. Other Metabolic Processes | 1 | ↓ | 1 | ||||
| CRYAB | Alpha crystallin B chain | 3. Stress Response and Apoptosis | 3 | ↓ | 1 | ||||
| GBG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 5. Cell Signaling | 2 | ↓ | 1 | ||||
| EDC4 | Enhancer of mRNA-decapping protein 4 | 6. Transcription and Translation Processes | 1 | ↓ | 1 | ||||
| d) Differentially Expressed Proteins Shared by CCC and IC patients | Total Spots‡ | CCC/N | IC/N | DCM/N | |||||
| Entry name* | Protein names† | Function | ↑↓ | S§ | ↑↓ | S§ | ↑↓ | S§ | |
| NDUS3 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial | 2.4. Oxidative Phosphorylation and Electron Transport | 2 | ↑ | 1 | ↑ | 1 | ||
| CHCH3 | Coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrial | 9. Other Functions | 2 | ↑ | 1 | ↑ | 1 | ||
| ACTN2 | Alpha-actinin-2 (Alpha actinin skeletal muscle isoform 2) | 1. Structural and Contractile Proteins | 4 | ↓ | 1 | ↓ | 1 | ||
| D3D2 | 3,2-trans-enoyl-CoA isomerase, mitochondrial | 2.2. Lipid Metabolism/ß-Oxidation | 1 | ↓ | 1 | ↓ | 1 | ||
| e) Differentially Expressed Proteins Shared by CCC and DCM patients | Total Spots‡ | CCC/N | IC/N | DCM/N | |||||
| Entry name* | Protein names† | Function | ↑↓ | S§ | ↑↓ | S§ | ↑↓ | S§ | |
| TBA1C | Tubulin alpha-1C chain | 1. Structural and Contractile Proteins | 1 | ↑ | 1 | ↑ | 1 | ||
| TBB5 | Tubulin beta-5 chain | 1. Structural and Contractile Proteins | 3 | ↑ | 2 | ↑ | 2 | ||
| IDH3A | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | 2.3. Tricarboxylic Acid Cycle | 2 | ↑ | 2 | ↑ | 1 | ||
| DPYL2 | Dihydropyrimidinase-related protein 2 | 2.6. Other Metabolic Processes | 1 | ↑ | 1 | ↑ | 1 | ||
| SCOT1 | Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial | 2.6. Other Metabolic Processes | 2 | ↑ | 1 | ↑ | 2 | ||
| ENPL | Endoplasmin precursor (Heat shock protein 90 kDa beta member 1) | 3. Stress Response and Apoptosis | 2 | ↑ | 1 | ↑ | 1 | ||
| GRP78 | 78 kDa glucose-regulated protein (Heat shock 70 kDa protein 5) | 3. Stress Response and Apoptosis | 3 | ↑ | 3 | ↑ | 3 | ||
| HS90A | Heat shock protein HSP 90-alpha | 3. Stress Response and Apoptosis | 1 | ↑ | 1 | ↑ | 1 | ||
| HSP71 | Heat shock 70 kDa protein 1 | 3. Stress Response and Apoptosis | 2 | ↑ | 1 | ↑ | 2 | ||
| PDIA1 | Protein disulfide-isomerase precursor | 3. Stress Response and Apoptosis | 1 | ↑ | 1 | ↑ | 1 | ||
| PDIA3 | Protein disulfide-isomerase A3 precursor | 3. Stress Response and Apoptosis | 2 | ↑ | 2 | ↑ | 2 | ||
| ANXA1 | Annexin A1 (Annexin I) | 3. Stress Response and Apoptosis | 1 | ↑ | 1 | ↑ | 1 | ||
| ANXA5 | Annexin A5 (Annexin V) | 3. Stress Response and Apoptosis | 2 | ↑ | 2 | ↑ | 2 | ||
| 1433Z | 14-3-3 protein zeta/delta | 5. Cell Signaling | 1 | ↑ | 1 | ↑ | 1 | ||
| SYAC | Alanyl-tRNA synthetase, cytoplasmic | 6. Transcription and Translation Processes | 3 | ↑ | 2 | ↑ | 1 | ||
| ZN658 | Zinc finger protein 658 | 6. Transcription and Translation Processes | 1 | ↑ | 1 | ↑ | 1 | ||
| MIB2 | E3 ubiquitin-protein ligase MIB2 | 8. Proteasome-Ubiquitin Process | 1 | ↑ | 1 | ↑ | 1 | ||
| RNF25 | E3 ubiquitin-protein ligase | 8. Proteasome-Ubiquitin Process | 1 | ↑ | 1 | ↑ | 1 | ||
| ANXA2 | Annexin A2 (Annexin II) | 9. Other Functions | 3 | ↑ | 3 | ↑ | 2 | ||
| F13A | Coagulation factor XIII A chain | 9. Other Functions | 1 | ↑ | 1 | ↑ | 1 | ||
| AMPL | Cytosol aminopeptidase | 9. Other Functions | 2 | ↑ | 2 | ↑ | 1 | ||
| PDZD4 | PDZ domain-containing protein 4 | 9. Other Functions | 1 | ↑ | 1 | ↑ | 1 | ||
| AINX | Alpha-internexin | 1. Structural and Contractile Proteins | 1 | ↓ | 1 | ↓ | 1 | ||
| MLRV | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform | 1. Structural and Contractile Proteins | 4 | ↓ | 1 | ↓ | 3 | ||
| MYL3 | Myosin light polypeptide 3 (Myosin light chain 1, slow-twitch muscle B/ventricular isoform) | 1. Structural and Contractile Proteins | 4 | ↓ | 2 | ↓ | 2 | ||
| TNNT2 | Troponin T, cardiac muscle | 1. Structural and Contractile Proteins | 7 | ↓ | 1 | ↓ | 1 | ||
| VIME | Vimentin | 1. Structural and Contractile Proteins | 1 | ↓ | 1 | ↓ | 1 | ||
| ALDOA | Fructose-bisphosphate aldolase A (Muscle-type aldolase) | 2.1. Glycolysis | 6 | ↓ | 1 | ↓ | 2 | ||
| ALDOC | Fructose-bisphosphate aldolase C (Brain-type aldolase) | 2.1. Glycolysis | 2 | ↓ | 2 | ↓ | 2 | ||
| ENOB | Beta-enolase (Skeletal muscle enolase) | 2.1. Glycolysis | 1 | ↓ | 1 | ↓ | 1 | ||
| K6PF | 6-phosphofructokinase, muscle type | 2.1. Glycolysis | 2 | ↓ | 1 | ↓ | 1 | ||
| PGAM2 | Phosphoglycerate mutase 2 | 2.1. Glycolysis | 2 | ↓ | 2 | ↓ | 2 | ||
| ACADM | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 2.2. Lipid Metabolism/ß-Oxidation | 1 | ↓ | 1 | ↓ | 1 | ||
| DECR | 2,4-dienoyl-CoA reductase, mitochondrial | 2.2. Lipid Metabolism/ß-Oxidation | 3 | ↓ | 1 | ↓ | 2 | ||
| DHSB | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | 2.3. Tricarboxylic Acid Cycle | 1 | ↓ | 1 | ↓ | 1 | ||
| FUMH | Fumarate hydratase, mitochondrial | 2.3. Tricarboxylic Acid Cycle | 3 | ↓ | 1 | ↓ | 1 | ||
| IDHP | Isocitrate dehydrogenase [NADP], mitochondrial | 2.3. Tricarboxylic Acid Cycle | 3 | ↓ | 3 | ↓ | 3 | ||
| ATP5H | ATP synthase D chain, mitochondrial | 2.4. Oxidative Phosphorylation and Electron Transport | 1 | ↓ | 1 | ↓ | 1 | ||
| NDUAA | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10 | 2.4. Oxidative Phosphorylation and Electron Transport | 1 | ↓ | 1 | ↓ | 1 | ||
| NDUV1 | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | 2.4. Oxidative Phosphorylation and Electron Transport | 4 | ↓ | 2 | ↓ | 1 | ||
| QCR1 | Cytochrome b-c1 complex subunit 1, mitochondrial | 2.4. Oxidative Phosphorylation and Electron Transport | 3 | ↓ | 2 | ↓ | 1 | ||
| QCR2 | Cytochrome b-c1 complex subunit 2, mitochondrial | 2.4. Oxidative Phosphorylation and Electron Transport | 1 | ↓ | 1 | ↓ | 1 | ||
| KCRS | Creatine kinase, sarcomeric mitochondrial | 2.5. Creatine Kinase System (Energy Transduction) | 5 | ↓ | 1 | ↓ | 1 | ||
| KU86 | ATP-dependent DNA helicase 2 subunit 2 | 2.6. Other Metabolic Processes | 1 | ↓ | 1 | ↓ | 1 | ||
| BLVRB | Flavin reductase | 2.6. Other Metabolic Processes | 1 | ↓ | 1 | ↓ | 1 | ||
| KAD1 | Adenylate kinase isoenzyme 1 | 2.6. Other Metabolic Processes | 2 | ↓ | 1 | ↓ | 1 | ||
| MDHC | Malate dehydrogenase, cytoplasmic | 2.6. Other Metabolic Processes | 3 | ↓ | 1 | ↓ | 1 | ||
| THIL | Acetyl-CoA acetyltransferase, mitochondrial | 2.6. Other Metabolic Processes | 1 | ↓ | 1 | ↓ | 1 | ||
| AKT2 | RAC-beta serine/threonine-protein kinase | 3. Stress Response and Apoptosis | 1 | ↓ | 1 | ↓ | 1 | ||
| NEIL1 | Endonuclease VIII-like 1 | 3. Stress Response and Apoptosis | 1 | ↓ | 1 | ↓ | 1 | ||
| PRDX2 | Peroxiredoxin-2 | 3. Stress Response and Apoptosis | 1 | ↓ | 1 | ↓ | 1 | ||
| PRDX3 | Peroxiredoxin-3 | 3. Stress Response and Apoptosis | 1 | ↓ | 1 | ↓ | 1 | ||
| PRDX6 | Peroxiredoxin-6 | 3. Stress Response and Apoptosis | 3 | ↓ | 1 | ↓ | 3 | ||
| KC1E | Casein kinase I isoform epsilon | 5. Cell Signaling | 1 | ↓ | 1 | ↓ | 1 | ||
| EIF3J | Eukaryotic translation initiation factor 3 subunit | 6. Transcription and Translation Processes | 1 | ↓ | 1 | ↓ | 1 | ||
| IF4H | Eukaryotic translation initiation factor 4H | 6. Transcription and Translation Processes | 1 | ↓ | 1 | ↓ | 1 | ||
| UCP2 | Mitochondrial uncoupling protein 2 | 7. Transport | 1 | ↓ | 1 | ↓ | 1 | ||
| EHD4 | EH domain-containing protein 4 | 9. Other Functions | 1 | ↓ | 1 | ↓ | 1 | ||
| GAB3 | GRB2-associated-binding protein 3 | 9. Other Functions | 1 | ↓ | 1 | ↓ | 1 | ||
| JKIP1 | Janus kinase and microtubule-interacting protein 1 | 9. Other Functions | 1 | ↓ | 1 | ↓ | 1 | ||
| MYG | Myoglobin | 9. Other Functions | 8 | ↓ | 2 | ↓ | 3 | ||
| PEBP1 | Phosphatidylethanolamine-binding protein 1 | 9. Other Functions | 1 | ↓ | 1 | ↓ | 1 | ||
| WDFY2 | WD repeat and FYVE domain-containing protein 2 | 9. Other Functions | 1 | ↓ | 1 | ↓ | 1 | ||
| f) Differentially Expressed Proteins Shared by IC and DCM patients | Total Spots‡ | CCC/N | IC/N | DCM/N | |||||
| Entry name* | Protein names† | Function | ↑↓ | S§ | ↑↓ | S§ | ↑↓ | S§ | |
| ECHM | Enoyl-CoA hydratase, mitochondrial | 2.2. Lipid Metabolism/ß-Oxidation | 1 | ↑ | 1 | ↑ | 1 | ||
| AOFB | Amine oxidase [flavin-containing] B | 2.6. Other Metabolic Processes | 1 | ↑ | 1 | ↑ | 1 | ||
| BPIL3 | Bactericidal/permeability-increasing protein-like 3 | 9. Other Functions | 1 | ↑ | 1 | ↑ | 1 | ||
| GSTP1 | Glutathione S-transferase P | 2.6. Other Metabolic Processes | 1 | ↓ | 1 | ↓ | 1 | ||
| g) Differentially Expressed Proteins Shared by CCC, IC and DCM patients | Total Spots‡ | CCC/N | IC/N | DCM/N | |||||
| Entry name* | Protein names† | Function | ↑↓ | S§ | ↑↓ | S§ | ↑↓ | S§ | |
| DESM | Desmin | 1. Structural and Contractile Proteins | 9 | ↑ | 4 | ↑ | 2 | ↑ | 8 |
| GELS | Gelsolin precursor (Actin-depolymerizing factor) | 1. Structural and Contractile Proteins | 6 | ↑ | 5 | ↑ | 1 | ↑ | 5 |
| LUM | Lumican precursor | 1. Structural and Contractile Proteins | 1 | ↑ | 1 | ↑ | 1 | ↑ | 1 |
| TNNI3 | Troponin I, cardiac muscle | 1. Structural and Contractile Proteins | 1 | ↑ | 1 | ↑ | 1 | ↑ | 1 |
| G6PI | Glucose-6-phosphate isomerase | 2.1. Glycolysis | 1 | ↑ | 1 | ↑ | 1 | ↑ | 1 |
| KPYM | Pyruvate kinase isozymes M1/M2 | 2.1. Glycolysis | 4 | ↑ | 1 | ↑ | 1 | ↑ | 3 |
| PGAM1 | Phosphoglycerate mutase 1 | 2.1. Glycolysis | 2 | ↑ | 2 | ↑ | 2 | ↑ | 2 |
| AL4A1 | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial | 2.4. Oxidative Phosphorylation and Electron Transport | 1 | ↑ | 1 | ↑ | 1 | ↑ | 1 |
| ATPA | ATP synthase subunit alpha, mitochondrial | 2.4. Oxidative Phosphorylation and Electron Transport | 8 | ↑ | 4 | ↑ | 3 | ↑ | 3 |
| DHSA | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | 2.4. Oxidative Phosphorylation and Electron Transport | 4 | ↑ | 2 | ↑ | 2 | ↑ | 2 |
| DLDH | Dihydrolipoyl dehydrogenase, mitochondrial precursor | 2.4. Oxidative Phosphorylation and Electron Transport | 4 | ↑ | 3 | ↑ | 1 | ↑ | 3 |
| CATD | Cathepsin D | 2.6. Other Metabolic Processes | 2 | ↑ | 1 | ↑ | 1 | ↑ | 1 |
| DHE3 | Glutamate dehydrogenase 1, mitochondrial | 2.6. Other Metabolic Processes | 1 | ↑ | 1 | ↑ | 1 | ↑ | 1 |
| MMSA | Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial | 2.6. Other Metabolic Processes | 1 | ↑ | 1 | ↑ | 1 | ↑ | 1 |
| TGM2 | Protein-glutamine gamma-glutamyltransferase 2 | 2.6. Other Metabolic Processes | 3 | ↑ | 3 | ↑ | 1 | ↑ | 3 |
| UGPA | UTP–glucose-1-phosphate uridylyltransferase | 2.6. Other Metabolic Processes | 1 | ↑ | 1 | ↑ | 1 | ↑ | 1 |
| GRP75 | Stress-70 protein, mitochondrial | 3. Stress Response and Apoptosis | 2 | ↑ | 2 | ↑ | 2 | ↑ | 2 |
| TRAF3 | TNF receptor-associated factor 3 | 3. Stress Response and Apoptosis | 2 | ↑ | 1 | ↑ | 1 | ↑ | 2 |
| CO3 | Complement C3 precursor | 4. Immune Response | 2 | ↑ | 1 | ↑ | 1 | ↑ | 2 |
| IGHG1 | Ig gamma-1 chain C region. | 4. Immune Response | 3 | ↑ | 3 | ↑ | 3 | ↑ | 3 |
| FRRS1 | Ferric-chelate reductase 1 | 7. Transport | 1 | ↑ | 1 | ↑ | 1 | ↑ | 1 |
| SNAB | Beta-soluble NSF attachment protein | 7. Transport | 1 | ↑ | 1 | ↑ | 1 | ↑ | 1 |
| ALBU | Serum albumin precursor | 9. Other Functions | 4 | ↑ | 4 | ↑ | 2 | ↑ | 4 |
| CSRP3 | Cysteine and glycine-rich protein 3 | 9. Other Functions | 1 | ↑ | 1 | ↑ | 1 | ↑ | 1 |
| IMMT | Mitochondrial inner Membrane protein (Mitofilin) | 9. Other Functions | 4 | ↑ | 3 | ↑ | 2 | ↑ | 3 |
| TRFE | Serotransferrin precursor (Transferrin) | 9. Other Functions | 4 | ↑ | 3 | ↑ | 3 | ↑ | 3 |
| YP016 | Uncharacterized protein MGC16385 | 9. Other Functions | 1 | ↑ | 1 | ↑ | 1 | ↑ | 1 |
| ACTC | Actin, alpha cardiac muscle 1 (Alpha-cardiac actin) | 1. Structural and Contractile Proteins | 15 | ↓ | 8 | ↓ | 1 | ↓ | 5 |
| LDB3 | LIM domain-binding protein 3 | 1. Structural and Contractile Proteins | 5 | ↓ | 5 | ↓ | 5 | ↓ | 5 |
| MYH7 | Myosin-7 (Myosin heavy chain, cardiac muscle beta isoform) | 1. Structural and Contractile Proteins | 2 | ↓ | 1 | ↓ | 1 | ↓ | 1 |
| AT5F1 | ATP synthase subunit b, mitochondrial | 2.4. Oxidative Phosphorylation and Electron Transport | 3 | ↓ | 2 | ↓ | 1 | ↓ | 2 |
| NDUV2 | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | 2.4. Oxidative Phosphorylation and Electron Transport | 1 | ↓ | 1 | ↓ | 1 | ↓ | 1 |
| KCRM | Creatine kinase M-type | 2.5. Creatine Kinase System (Energy Transduction) | 5 | ↓ | 5 | ↓ | 2 | ↓ | 5 |
| AATC | Aspartate aminotransferase, cytoplasmic | 2.6. Other Metabolic Processes | 3 | ↓ | 2 | ↓ | 2 | ↓ | 2 |
*Entry name: Mnemonic identifier for a UniProtKB entry, all the entry names are followed by “_HUMAN”; †Protein names: Name of the protein according to UniProtKB; ‡Total spots: Number of spots identified as such protein; §S: Number of differentially expressed spots identified as such protein for each comparison. Other annotations and comments, fold change and statistical values, as well as protein identification score values of all identified spots are included in the Supplemental Table 2 from Online Supplemental Data .
↑ means upregulated expression ↓ means downregulated expression.