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Schematic concepts of EO culture system and ESCC study model
Mouse esophageal organoids are developed from single cells of esophageal tissue in E-MEOM. EOs in E-MEOM recapitulate cellular heterogeneity, differentiation, and stemness of human esophageal epithelial cells. EO culture in E-MEOM potentiates an applicable model for ESCC pathology with oncogenic Kras mutation and Trp53 deletion.
