Figure 6.

Structural models of GTP binding to eIF2 and eIF2B during complex interactions

(A and B) Model of eIF2 bound to eIF2B in eIF2αP sensing mode and (B) detail of potential GTP-binding sites. GDPCP (GTP analog) modeled from eIF2 ternary complex (3JAP) added in black to eIF2γ (salmon) and GTP from GDP-mannose pyrophosphorylase (2X60) added in standard atom colors to eIF2Bγ (light green).

(C) As panel A but depicting eIF2 bound engaging fully with eIF2Bepsilon.

(D) Zoomed detail of modeled nucleotide binding, as described for panel B.