Table 2.

Association of type 2 diabetes mellitus (T2DM) and/or hypertension (HTN) with combined vascular events and stroke compared with the non-T2DM and non-HTN

	Combined vascular event (VE)		Stroke
	HR (95% CI)	P value	HR (95% CI)	P value
Unadjusted
Non-T2DM and non-HTN	1 (reference)		1 (reference)
T2DM-only	1.747 (1.566 to 1.949)	<0.0001	2.077 (1.755 to 2.459)	<0.0001
HTN-only	6.246 (5.712 to 6.830)	<0.0001	8.642 (7.517 to 9.934)	<0.0001
T2DM and HTN	4.930 (4.93 to 5.474)	<0.0001	5.990 (5.102 to 7.032)	<0.0001
Age-adjusted and sex-adjusted
Non-T2DM and non-HTN	1 (reference)		1 (reference)
T2DM-only	1.258 (1.127 to 1.405)	<0.0001	1.464 (1.235 to 1.735)	<0.0001
HTN-only	3.344 (3.046 to 3.670)	<0.0001	4.409 (3.817 to 5.093)	<0.0001
T2DM and HTN	2.595 (2.329 to 2.892)	<0.0001	3.021 (2.561 to 3.563)	<0.0001
Risk factors-adjusted
Non-T2DM and non-HTN	1 (reference)		1 (reference)
T2DM-only	1.332 (1.134 to 1.565)	0.0005	1.584 (1.246 to 2.014)	<0.0001
HTN-only	3.244 (2.946 to 3.572)	<0.0001	4.543 (3.918 to 5.268)	<0.0001
T2DM and HTN	3.002 (2.577 to 3.497)	<0.0001	4.151 (3.346 to 5.149)	<0.0001

Risk factors include age, sex, triglycerides, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol.

HTN, hypertension; T2DM, type 2 diabetes mellitus; VE, combined vascular event.