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Berberine upregulated FTO via downregulating β-catenin. After Berberine treatment, activating wnt signaling or knockdown β-catenin for 48 h, FTO mRNA levels (A) and protein levels (B) were measured. *p < 0.05, vs. mock group; #p < 0.05, vs. Berberine-treated group; &p < 0.05, vs. shScrambled group.
