Table 1.

Assembled essential gene information based on OGEE (21), DEG (26) and the literature

Species	Source	Data set abbreviation	Method	Essential genes	Non essential genes
H. sapiens	Population sequencing data	Hs OE	Loss-of fuction-variants (50–54)	2828	12 844
H. sapiens	Cell line	Hs CE	RNAi (43,47,63), shRNA (48), CRISPR (14–16)	833	13 743
M. musculus	Organism	Mm OE	Biallelic inactivation (56,62)	1966	4505
M. musculus	Cell line	Mm CE	CRISPR (57)	939	7472
D. melanogaster	Organism	Dm OE	P-element (59), RNAi (44), CRISPR (58)	246	271
D. melanogaster	Cell line	Dm CE	RNAi (61), CRISPR (55)	1227	10 320
C. elegans	Organism	Ce OE	RNAi (60)	737	10 128
S. cerevisiae	Single cell	Sc CE	PCR based (7,45,21)	1036	4373
S. pombe	Single cell	Sp CE	PCR based (46), Transposon (49)	1226	3379
			Total	11 038	67 035