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The optimization of dosage schedule. (A) The vaccination schedule. BALB/c mice were vaccinated intramuscularly with vaccines in groups of six as indicated, then the mice were sacrificed at 2 weeks after the final vaccination for assays of IgG binding antibody and neutralizing antibody responses. (B) The S1-specific antibody responses. (C) The neutralizing antibody titer. Data are shown as mean values (mean ± SD) for each group of six mice.
