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Model of calmodulin docking on Munc13-2 and the effect of variants. (A) Complex of wild-type (WT) Munc13-2 and calmodulin. (B–D) Complex of mutant Munc13-2 and calmodulin. (C) Gly794Asp alters the docking site, interface area and Gibbs free energy of Munc13-2.
