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. 2021 Apr 20;144(10):3050–3060. doi: 10.1093/brain/awab164

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© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Representative EEG recordings and MRI from patients with UNC13B variants. (A) Interictal EEG in Case 1 showed left occipital slow spike waves. (B) Interictal EEG in Case 3 showed left central-temporal slow spike waves. (C and D) Interictal EEG in Case 8 showed spikes or sharp waves in the left or right temporal lobe, or of slow spike waves in the right frontal lobe. (E and F) Coronal and axial T₂-FLAIR MRI of Case 8 revealed structural asymmetry in the hippocampus; the right hippocampus was smaller than the left one, with a slightly higher signal. The boundary between the left hippocampus and surrounding tissues was indistinct.