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. 2021 Apr 20;144(10):3050–3060. doi: 10.1093/brain/awab164

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© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Knockdown of Unc13b induces seizure-like behaviour in Drosophila. (A) Behaviour in the BS paralysis test; the three stages observed in Unc13b knockdown flies were seizure (manifesting as vibrating wings, circled in red), paralysis and recovery. (B) Seizures occurred at a higher rate in Unc13b knockdown flies (tub-Gal4>Unc13b-RNAi) than in wild-type (WT) flies (Canton-S) and tub-Gal4>Chd3-RNAi and other control groups. The tub-Gal4>Scn1a-RNAi positive controls had a higher rate of seizures than the tub-Gal4>Unc13b-RNAi group. (C) The recovery time from seizure was longer in tub-Gal4>Unc13b-RNAi than in Canton-S but shorter than in tub-Gal4>Scn1a-RNAi.