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. 2021 Apr 20;144(10):3050–3060. doi: 10.1093/brain/awab164

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© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Unc13b knockdown induces increased neural excitability in projection neurons. (A) Representative trace of extracellular electrical activity in Canton-S wild-type (WT) projection neurons showing sporadic action currents. (B) Regular high-frequency burst firing was recorded in projection neurons of tub-Gal4>Unc13b-RNAi flies. (C) Action current frequency was significantly higher in tub-Gal4>Unc13b-RNAi than in Canton-S. (D) There was no difference in amplitude of action currents between tub-Gal4>Unc13b-RNAi and Canton-S.