Figure 3.
Sex modifies the APOE ε4 dosage effect on region of interest-based analysis of 18F-flortaucipir PET in cognitively impaired individuals. Box plots depict median value and the interquartile ranges of regional SUVRs for APOE ε4 non-carriers (green), heterozygotes (purple) and homozygotes (red) in females and males. P-value was defined using a generalized linear model, adjusting for age and years of education. F = female; M = male. Bold significance lines indicate comparison between APOE ε4 dosage groups. *P < 0.05, **P < 0.01, ***P < 0.001.